P137 Main trial results of the EVAQ clinical study for the Q revascularization system in acute ischemic stroke
Year: 2024
Type: conference-abstract
Abstract: Introduction The Q Revascularization System is a novel thrombectomy device which aims to improve aspiration efficacy by increasing the system inner diameter. The larger diameter allows for greater impulse and acceleration of aspiration than traditional aspiration systems. Aim of Study Report the results of the EVAQ clinical study, Methods EVAQ is a prospective, single arm study with CEC and Core Lab assessed endpoints studying Q for the primary treatment of LVOs within 8hrs of symptom onset. Primary efficacy and safety endpoints are final mTICI2b-3 and sICH. Pre-specified secondary endpoints include revascularization after use of Q, first pass reperfusion and mRS0-2 at 90 days. Results The EVAQ study enrolled one hundred twenty-three subjects at 17 centers in France and the US from November 2020 to April 2023. Mean age was 68.3. Females were 52.8%. Mean NIHSS and ASPECTS were 15.8±5.9 and 8.1±1.5 respectively. Sites of large vessel occlusion treatment were Basilar 3.3%, ICA 13.9%, M1 MCA 64.2%, M2 MCA 17.1%, and other anterior location 1.6%. IV thrombolysis was administered in 55.5% of subjects. Onset to arterial puncture was 4.58 hours ±2.04. The primary outcome, final mTICI2b-3 by independent imaging core lab, was achieved in 93.9% of subjects. CEC adjudicated sICH per ECASS was 6.5%. Revascularization after the use of Q alone was 78.8% and first pass success was 56.7%. Time from groin puncture to successful revascularization was a mean of 38.2 minutes. Conclusion The novel Q Revascularization System is safe and effective for revascularization of Large Vessel Occlusions in acute ischemic stroke. Disclosure of Interest no.
Source: Abstracts
Authors: Christophe Cognard, Brian Jankowitz, Lucas Elijovich, Benjamin Gory, Romain Bourcier, Xavier Barreau, Federico Di Maria, Laurent Spelle, Maxim Mokin, Adnan Siddiqui, Jazba Soomro, Omer Eker, Clemens Schirmer, Ashutosh Jadhav, Hamza Shaikh, Charles Matouk, Michael Stiefel, M Taqi, Jean Darcourt, Leon Ikka, Gaultier Marnat, Kunal Vakharia, Guillaume Bellanger, Florent Gariel, Alessandro Sgreccia, Pierre Louis Alexandre, Liang Liao, Morgane Laubacher, Jason Davies, Anne-Christine Januel, Hubert Desal, Osman Mir, Roberto Riva, Silvia Pizzuto, David Liebeskind
Institutions: Centre Hospitalier Universitaire de Toulouse, Hôpital Purpan, John F. Kennedy Medical Center, Semmes Murphey Foundation, Centre Hospitalier Régional et Universitaire de Nancy, Centre Hospitalier Universitaire de Nantes, Nantes Université, Centre Hospitalier Universitaire de Bordeaux, Hôpital Foch, Bicêtre Hospital, University of South Florida, Jacobs Institute, University at Buffalo, State University of New York, Hospices Civils de Lyon, Barrow Neurological Institute, Cooper University Health Care, Yale University, Piedmont Atlanta Hospital, University of California, Los Angeles
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4402218213