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JC Polyomavirus Nephropathy: A Rare Complication Late after Kidney Transplantation

Year: 2024

Type: article

Abstract: Introduction: JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only a few cases described in the literature. Case Presentation: We present 2 cases of JC-PVAN, both of which occurred >5 years after kidney transplantation. In both cases, transplant biopsies were performed because of worsening of kidney function. We found tubulitis and interstitial inflammation; immunohistochemistry was positive for SV40, but BK virus was not detected. The presence of JC virus confirmed the diagnosis of JC-PVAN. Immunosuppressive therapy was adopted, but in both cases graft function progressively deteriorated. Conclusions: Our cases show that JC-PVAN, although much rarer than BK-PVAN, should be considered a possible cause of graft dysfunction even years after transplantation. Complete diagnostic workup, including kidney biopsy, is crucial for correct diagnosis and treatment.

Source: Case Reports in Nephrology and Dialysis

DOI: 10.1159/000540294

Authors: Jennifer Scotti Gerber, Sara De Marchi, Ariana Gaspert, Thomas Fehr, Pietro E. Cippà

Institutions: Ente Ospedaliero Cantonale, Università della Svizzera italiana, University Hospital Zurich, University of Zurich, Kantonsspital Graubünden

Language: English

Topic: Polyomavirus and related diseases

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030