Figure 4 from Poor Prognosis among Radiation-Associated Bladder Cancer Is Defined by Clinicogenomic Features
Year: 2024
Type: other
Abstract: Comparison of the copy number landscape between CTRL and RT tumors. A, Copy number status, as determined by the FoundationOne CDx assay, was plotted by the number of tumors with a given alteration (gains = positive value, losses = negative values). Groups are shown as CTRL (gold), RT–short latency (dark blue), and RT–long latency (light blue). Significant enrichment was calculated using the Fisher exact test, and P < 0.05 is indicated by an asterisk (*). Patients were separated by latency, (B) CTRL, (C) short Latency, and (D) long latency, and OS differences between chr9p21.3 WT and loss (as determined by CDKN2A/B copy number status) were visualized using KM curves. Log rank P value was calculated for the pairwise comparison. Patients were then separated by CKDN2A/B copy number status to compare the difference in OS between the latency group within (E) deleted or (F) copy number neutral tumors. G, RT samples in the DFCI cohort were grouped by CDKN2A/B loss (GISTIC2 value <0.5), and OS was visualized. For all KM plots, dashed lines indicate median survival. WT, wild type.
Authors: N. Ari Wijetunga, Kathryn H. Gessner, Krishna Kanchi, Jay A. Moore, Zoe Fleischmann, Dexter X. Jin, Garrett M. Frampton, Michael Sturdivant, Michael Repka, Shivani Sud, David L. Corcoran, Matthew D. Galsky, Matthew I. Milowsky, Sara E. Wobker, William Y. Kim, Tracy L. Rose, Jeffrey S. Damrauer
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4402239763