Figure 1 from Poor Prognosis among Radiation-Associated Bladder Cancer Is Defined by Clinicogenomic Features
Year: 2024
Type: other
Abstract: Construction and clinical characterization of the RT and CTRL cohorts. A, Flowchart representing identification and filtering of patients included or excluded in each cohort. Barplots of distribution of (B) T, (C) N, and (D) M stage tumors for both the CTRL and RT cohorts. Bar height represents the proportion of cohort with the absolute number inset in the respective box. Fisher exact test was performed to calculate significance between CTRL and RT sample distribution. E, Kaplan–Meier (KM) curves representing OS for patients with CTRL (gold), RT–short latency (dark blue), and RT–long latency (light blue) tumors. F, KM curves representing OS for RT patients grouped by smoking status at the time of the bladder cancer diagnosis. For KM curves, dashed lines indicate median survival. Significance was calculated using the Cox proportional hazard model with CTRL and never smokers as the reference, respectively. G, Forest plot visualizing a multivariate Cox proportional model for OS incorporating smoking and latency. Reference groups are indicated within the figure. H, Swimmer plot showing time from RT to end of follow-up. Solid black lines represent the age of patients at the time of prostate RT. The x-axis origin denotes the time of RT, with the teal bar length proportional to the latency and the pink bar indicating length of follow-up to death or last follow-up. Vital status is noted by either a circle (alive at last follow-up) or a triangle (deceased). UTUC; upper tract urothelial carcinoma.
Authors: N. Ari Wijetunga, Kathryn H. Gessner, Krishna Kanchi, Jay A. Moore, Zoe Fleischmann, Dexter X. Jin, Garrett M. Frampton, Michael Sturdivant, Michael Repka, Shivani Sud, David L. Corcoran, Matthew D. Galsky, Matthew I. Milowsky, Sara E. Wobker, William Y. Kim, Tracy L. Rose, Jeffrey S. Damrauer
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4402243292