Evaluation of Antifungal Activity of MaxilloFacial Silicone Elastomer Reinforced with Chitosan Nanoparticles—An In vitro Study
Year: 2024
Type: article
Abstract: Background: , is a major issue with the usage of maxillofacial silicone material, which can lead to chronic infection, inflammation, and silicone material degradation, for which the development of an antimicrobial silicone elastomer has become crucial. Methodology: This study was designed to determine the efficacy of adding chitosan nanoparticles (1.5%, 3%, and 5% by weight) to silicone matrix on antifungal activity. Eighty specimens were fabricated with varying concentrations of chitosan and separated into four groups [C1 (control), C2 (1.5%wt chitosan reinforced silicone), C3 (3%wt chitosan/silicone), and C4 (5%wt chitosan/silicone)]. An antifungal test was conducted on each group. Results: The inhibition zone was concentration dependent in antifungal tests; as the concentration increased, the inhibition zone grew as well. Conclusion: Improvement in the antifungal activity of silicone was demonstrated when chitosan nanoparticles were incorporated.
Authors: Ailneni Nivya Sri, Shruti Vishal Dev, Sonali Perti, Nirmala Poddar, Sourav Kumar Pati, Pritam Das
Institution: GITAM University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $250
OpenAlex ID: W4402259617