Organizing the coactivity structure of the hippocampus from robust to flexible memory
Year: 2024
Type: article
Abstract: New memories are integrated into prior knowledge of the world. But what if consecutive memories exert opposing demands on the host brain network? We report that acquiring a robust (food-context) memory constrains the mouse hippocampus within a population activity space of highly correlated spike trains that prevents subsequent computation of a flexible (object-location) memory. This densely correlated firing structure developed over repeated mnemonic experience, gradually coupling neurons in the superficial sublayer of the CA1 stratum pyramidale to whole-population activity. Applying hippocampal theta-driven closed-loop optogenetic suppression to mitigate this neuronal recruitment during (food-context) memory formation relaxed the topological constraint on hippocampal coactivity and restored subsequent flexible (object-location) memory. These findings uncover an organizational principle for the peer-to-peer coactivity structure of the hippocampal cell population to meet memory demands.
Source: Science
Institutions: University of Oxford, MRC Brain Network Dynamics Unit
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Awards: G1321802161, G2665688118, Circuit-driven neuromodulation in the cognitive domain, Physiopathology of brain-wide assemblies in adaptive memory, Hippocampal-Hypothalamic Network Mechanisms of Maladaptive Contextual Eating, G5242262527, The role of adult-born dentate granule cells in hippocampal information processing and memory function., Circuit-level mechanisms of memory consolidation, G8195542982, G8543399002
OpenAlex ID: W4402260491