Work

Biological Evaluation of a Library of Thiamine-like 1,2,3-Triazoles Towards the Inhibition of DXP Synthase

Year: 2024

Type: article

Abstract: Objective: The non-mevalonate pathway (MEP pathway) in bacteria is responsible for synthesizing DMAPP and IPP, critical precursors in the biosynthesis of isoprenoids. DXP synthase is a key enzyme in this pathway, and its absence in humans makes it a promising target in the development of potentially newer antibiotics. Thiamine diphosphate (ThDP; Vitamin B1) is a cofactor responsible for the C-C bond formation between pyruvate and glyceraldehyde-3-phosphate to yield 1-Deoxy-D-xylulose 5-phosphate (DXP).

Source: American Journal of Pharmaceutical Education

DOI: 10.1016/j.ajpe.2024.101205

Authors: Shreyas Rama Murthy, Anand Sridhar

Institution: Massachusetts College of Pharmacy and Health Sciences

Language: English

Topic: Plant biochemistry and biosynthesis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400