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Inside Back Cover: In vivo Metabolic Sensing of Hyperpolarized [1‐13C]Pyruvate in Mice Using a Recyclable Perfluorinated Iridium Signal Amplification by Reversible Exchange Catalyst

Year: 2024

Type: article

Abstract: Real-time in vivo metabolic flux tracking in MIA PaCa-2 human pancreatic xenografts via MRI is made possible with [1-13C]pyruvate hyperpolarized through Signal Amplification By Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH). The use of a perfluorinated iridium SABRE catalyst in a fluorinated solvent and methanol blend allowed efficient separation from hyperpolarized pyruvate, ensuring biocompatibility and recyclability, and resulting in a 22 % increase in the hyperpolarized [1-13C]pyruvate signal. More details can be found in the Research Article by Jessica Ettedgui and co-workers (e202407349).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202416103

Authors: Jessica Ettedgui, Kazutoshi Yamamoto, Burchelle Blackman, Norikazu Koyasu, Natarajan Raju, Olga Vasalatiy, Hellmut Merkle, Eduard Y. Chekmenev, Boyd M. Goodson, Murali C. Krishna, Rolf E. Swenson

Institutions: National Heart, Lung, and Blood Institute, National Cancer Institute, Center for Cancer Research, National Institute of Neurological Disorders and Stroke, Wayne State University, The Barbara Ann Karmanos Cancer Institute, Southern Illinois University Carbondale

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4402269907

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