Work

Characterization of the Enantiomeric Purity of Molnupiravir in Presence of its Active Metabolite

Year: 2024

Type: article

Abstract: Objective: A novel HPLC chiral separation technique was developed for the determination of enantiomeric purity of R,S‐Molnupiravir in the presence of its active metabolite β-D-N4-hydroxycytidine (NHC) and subsequent quantification in different dosage forms. In the present study, we used a reversed‐phase high‐performance liquid chromatography with a chiral stationary phase consisting of Bonded Macrocylic Glycopeptide Teicoplanin Aglycone coated on silica‐gel (Astec® CHIROBIOTIC® TAG).

Source: American Journal of Pharmaceutical Education

DOI: 10.1016/j.ajpe.2024.100915

Authors: Ahmed M. Ali, Rashmi Kothiya, Maryglad Komo, Vincent Englebert Sy-Siong

Institution: Notre Dame of Maryland University

Language: English

Topic: Analytical Chemistry and Chromatography

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400