Work

Total Synthesis and Anticancer Potential of Sphingoid Natural Products Targeting Mitochondrial Membrane Potential.

Year: 2024

Type: article

Abstract: Objective: Ceramide is an apoptotic sphingolipid. The strategies aimed at increasing cellular ceramide induced apoptosis in several cancer cells. Jaspine B and Spisulosine have structural resemblances to ceramide and have the potential to interfere with the function of ceramide-derived membranes. Our objective is to develop a robust total synthesis of spisulosine and its analogs, gram scale synthesis of jaspine B and its analogs. Perform in vitro and in vivo studies for anticancer potential.

Source: American Journal of Pharmaceutical Education

DOI: 10.1016/j.ajpe.2024.100789

Authors: Srinath Pashikanti, Sameena Mateen, Jared Barrott, Ali Aghazadeh Habashi, Jordan Oman

Institutions: Idaho State University, Brigham Young University

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400