Work

Effect of SGLT2 Inhibitors on Fibroblast Activation

Year: 2024

Type: article

Abstract: Objective: To establish an in-vitro model and evaluate the cardioprotective potential for sodium-linked-glucose transporter 2 inhibitors (SGLT2i) in fibroblasts. We hypothesize that fibroblasts exposed to glucose experience oxidative stress and are sensitized to pathological stimuli such as TGFβ due to depletion of a protective antioxidant pathway.

Source: American Journal of Pharmaceutical Education

DOI: 10.1016/j.ajpe.2024.100778

Authors: Janet Lighthouse, Lauren St. John, Alicia Bill, Eden Kiflom-Halldow, Bugra Ozer, Nicole Henry

Institution: St. John Fisher University

Language: English

Topic: Diabetes Treatment and Management

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400