Work

miR-146a; A Potential Link Connecting Shear Stress-Induced Activation of Osteopontin & TLR-4 Pathways

Year: 2024

Type: article

Abstract: Objective: Our preliminary studies showed increased levels of Osteopontin (OPN), a shear-sensitive matricellular protein that promotes vascular inflammation, along with its receptor alphaV-Beta3 and downstream TRAF6, in Human Aortic Endothelial Cells (HAECs) subjected to oscillatory shear-stress (OSS) versus unidirectional shear stress (USS) control conditions. The goal of our work is to evaluate whether the over-expression of miR-146a can modulate OSS-induced expression levels of OPN and associated TLR-4 downstream signaling pathways.

Source: American Journal of Pharmaceutical Education

DOI: 10.1016/j.ajpe.2024.100833

Authors: Xinge Zheng, Eurasia Vue, Vy K. Tran Lu, Islam N. Mohamed

Institution: California Northstate University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400