Work

Development and in Vitro Evaluation of Topical Multi-drug Nanomicelles for Treatment of Corneal Injury

Year: 2024

Type: article

Abstract: Objective: Corneal healing is a critical process for restoring corneal integrity and maintaining vision after corneal injury. Based on the anatomical barriers possessed by cornea, our goal was to develop amphiphilic nanomicelles (NMs), which offer advantage of penetration and permit the drugs to reach the target site and improve their bioavailability. We have developed and evaluated PCL/PEG-based NMs loaded with dexamethasone (DEX), rapamycin (RAPA), and ciprofloxacin (CIP) for corneal treatment.

Source: American Journal of Pharmaceutical Education

DOI: 10.1016/j.ajpe.2024.100919

Authors: Brooke T. Robbins, Neeraj Thakur, Kate A. Montreuil, Iulia Rus, Vibhuti Agrahari

Institution: University of Oklahoma

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400