Enhancing Sensitivity in Nucleic Acid Detection via Collaborative Multiple Catalytic Cores in DNAzyme Nanomachines
Year: 2024
Type: article
Abstract: We introduce a multicore DNA nanomachine (MDNM), utilizing four binary DNAzymes for nucleic acid detection without the need for a preamplification step. This innovation remarkably yields a reduction in limit of detection (LOD), over 5-fold, as compared to single-core systems. This reduces the required test time thus highlighting the potential of MDNM in advancing nucleic acid detection.
Source: ChemBioChem
Authors: Zain Hussein, Lidia A. Golovina, Meera Alaji, Moustapha A. Y. Nour, Dmitry M. Kolpashchikov, Andrey B. Komissarov, Ahmed A. El‐Deeb
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funder: ITMO University
Awards: G1482437928, G8613546611
OpenAlex ID: W4402273147