Year: 2024
Type: article
Abstract: Histiocytic neoplasms constitute a group of rare hematologic neoplasms characterized by the accumulation of neoplastic histiocytic/dendritic cells with associated inflammatory infiltrate [ 1 ]. Central nervous system (CNS) involvement of these neoplasms is associated with increased morbidity and mortality [ 2 , 3 ]. Contrast-enhanced brain and spine MRI is the current standard for evaluating for the presence of CNS disease and monitoring response to treatment [ 4 ]. Neurofilament light chain (NfL) is a recently identified biomarker of axonal degeneration that has been utilized in monitoring disease activity in a wide variety of neurologic diseases [ 5 ]. It has extensive potential clinical utility as it can be tested in blood. The aim of this study was to evaluate if elevated NfL in patients with histiocytic neoplasms is associated with CNS involvement and active CNS disease.
Source: Blood Cancer Journal
Authors: Samantha A. Banks, Paul Decker, Eoin P. Flanagan, Anastasia Zekeridou, Ronald S. Go, Jithma P. Abeykoon, Gaurav Goyal, Jason R. Young, Matthew J. Koster, Robert Vassallo, Jay H. Ryu, Caroline J. Davidge-Pitts, Aishwarya Ravindran, Julio C. Sartori Valinotti, N. Nora Bennani, Mithun V. Shah, Karen L. Rech, Corrie R. Bach, Jeanette E. Eckel-Passow, W. Oliver Tobin
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,990
OpenAlex ID: W4402273452