The mechanism and treatment strategies of GSDMD-mediated pyroptosis in myocardial infarction
Year: 2024
Type: article
Abstract: Acute myocardial infarction (MI) is associated with high morbidity and mortality and poses a significant challenge to human health. Despite advances in medicine, effective treatment options for MI are still associated with adverse outcomes, such as heart failure. Consequently, identifying the pathogenesis of MI is a promising avenue for developing practical treatments. The inflammatory response plays a critical role in the pathogenesis of MI. Gasdermin D (GSDMD)-mediated pyroptosis regulates the inflammatory response, which is a pathogenic and potential therapeutic target for MI. Therefore, anti-pyroptosis treatment is emerging as a promising therapeutic approach for MI. Overall, this article reviews the mechanism and treatment strategies for GSDMD-mediated pyroptosis in MI, with the hope of providing insights into pathogenic interventions.
Source: Acupuncture and Herbal Medicine
Authors: Yujuan Li, Yaozu Xiang, Jiayi Liang, Yang Chen
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4402273706