Year: 2024
Type: conference-abstract
Abstract: Systemic lupus erythematosus (SLE) is a systemic disease with cardiac manifestations, of which pericarditis is the most common (a lifetime risk of 25%) 1 and myocarditis a less common (5–10%)2 but more severe manifestation. Both may occur in flares. Sometimes the cardiac presentation of pericarditis or myocarditis is the first presentation of lupus, therefore any presentation of pericarditis or myocarditis should be followed up with appropriate serology testing for SLE. A lupus myocarditis can be a severe presentation, necessitating circulatory support. Additional investigations are necessary and include cardiac magnetic resonance imaging2 3 and often a myocardial biopsy revealing a typical lymphocytic infiltration.4 A case will be presented. Therapy consisted of 3 days of high dose prednisolone, followed by cyclophosphamide in combination with prednisolone, followed by anti-TNF-α blockade.5References Moder KG, Miller TD, Tazelaar HD. Cardiac involvement in systemic lupus erythematosus. Mayo Clin Proc. 1999;74(3):275–84. doi: 10.4065/74.3.275.du Toit R, Karamchand S, Doubell AF, et al. Lupus myocarditis: Review of current diagnostic modalities and their application in clinical practice. Rheumatology (Oxford). 2023;62(2):523–34. doi: 10.1093/rheumatology/keac409.Mavrogeni S, Bratis K, Markussis V, et al. The diagnostic role of cardiac magnetic resonance imaging in detecting myocardial inflammation in systemic lupus erythematosus. Differentiation from viral myocarditis. Lupus. 2013;22(1):34–43. doi: 10.1177/0961203312462265.Gartshteyn Y, Tamargo M, Fleischer S, et al. Endomyocardial biopsies in the diagnosis of myocardial involvement in systemic lupus erythematosus. Lupus. 2020;29(2):199–204. doi: 10.1177/0961203319897116.Thomas G, Cohen Aubart F, Chiche L, et al. Lupus myocarditis: Initial presentation and longterm outcomes in a multicentric series of 29 patients. J Rheumatol. 2017;44(1):24–32. doi: 10.3899/jrheum.160493.Learning Objectives At the end of this presentation participants will be able to:Differentiate between pericarditis and myocarditis as presenting features of SLEExplain the importance of serological testing for SLE in patients with suspected pericarditis or myocarditisDiscuss the role of cardiac MRI and myocardial biopsy in diagnosing lupus myocarditis
Source: Abstracts
Author: Wouter Kok
Institution: Amsterdam University Medical Centers
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4402273816