Work

The Quinine Odyssey: A Barometer of the State of Organic Synthesis Over Centuries

Year: 2024

Type: article

Abstract: anniversary of the landmark formal synthesis of (±)-quinine completed by Woodward and Doering. This article examines the evolution of approaches to access this storied Cinchona alkaloid natural product which represent a microcosm the progress that has been made in organic synthesis over the past ~170 years. Seminal contributions led by Pasteur, Rabe, Woodward, Uskoković, Stork, Jacobsen, Hayashi, Maulide and others are discussed.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202403021

Author: Alex C. Bissember

Institution: University of Tasmania

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,640

Funder: Australian Research Council