Work

Queuosine salvage in Bartonella henselae Houston 1: a unique evolutionary path

Year: 2024

Type: article

Abstract: Graphical Abstract The substrate specificity of bacterial TGT and Q precursor transporter protein shifts from preQ1 to the queuine base in intracellular human pathogens such as Chlamydia trachomatis, driven by adaptation to the intracellular environment. The facultative intracellular pathogen Bartonella henselae exhibits a rare dual-substrate specificity for these Q salvage enzymes that represents an evolutionary transition state.

Source: Microbiology

DOI: 10.1099/mic.0.001490

Authors: Samia Quaiyum, Yifeng Yuan, Guangxin Sun, R. M. Madhushi N. Ratnayake, Geoffrey Hutinet, Peter C. Dedon, Michael F. Minnick, Valérie de Crécy-Lagard

Institutions: University of Florida, Massachusetts Institute of Technology, Vanderbilt University, Haverford College, University of Montana

Language: English

Topic: Bartonella species infections research

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: diamond

Funders: National Research Foundation, National Research Foundation Singapore, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Environmental Health Sciences

Awards: G1960556654, G3163982830, G4085340949, G4609563272, Translational Control of ROS Management, G7775750207, G845977543, G9000095573, G9000204493, G9000304856

OpenAlex ID: W4402276418

FWCI: 1.423

Cites: 56

Cited by: 4

Related to: 10