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The Role of Neutrophils in ARDS and Drugs that Modify their Formyl Peptide Receptor Activity

Year: 2024

Type: article

Abstract: Adult Respiratory Distress Syndrome (ARDS) represents a sustained neutrophil driven attack on the lung, where raised alveolar neutrophil numbers are known to predict severity and mortality. Neutrophil infiltration to the lung is in response to released Formyl Peptides from infected and damaged tissue which can drive oxidant and protease release with toxic effects. Formyl Peptides can stimulate neutrophils directly via their surface Formyl Peptide Receptors (FPR’S), escalating their activation and cytokine release. Highly stimulated and stressed neutrophils can be driven to release their nuclear material as Neutrophil Extracellular Traps, producing additional damage and arterial obstruction with increased hypoxaemia and mortality in ARDS.

Source: International Journal of Critical Care and Emergency Medicine

DOI: 10.23937/2474-3674/1510163

Authors: Varney Veronica A, Chattopadhyay Gopal, Sai Vishnu Bharadwaj, Monir Samina, Ray Abhishek, Nicholas Alex, Ford Brian, Quirke Ginny, Bansal Amolak, Quadery Syed Rehan

Institutions: St Helier Hospital, Epsom and St Helier University Hospitals NHS Trust

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402277871

FWCI:

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Related to: 10