Subjective cognitive decline and cognitive change among diverse middle‐aged and older Hispanic/Latino adults: Results from the Study of Latinos–Investigation of Neurocognitive Aging (SOL‐INCA)
Year: 2024
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: The potential utility of subjective cognitive decline (SCD) as an early risk marker of Alzheimer's disease and related dementias is under consideration. We examined associations between SCD and cognitive change among middle-aged and older Hispanic/Latino adults living in the United States. METHODS: The short-form Everyday Cognition Scale (ECog-12) was assessed to generate global, executive function, and memory-related SCD scores. We used survey generalized regressions to model the change in learning, memory, verbal fluency, executive function, and global cognitive performance over 7 years as a function of SCD (at Visit 2). RESULTS: The mean age was 56.37 ± 8.10 years at Visit 1 (n = 6225). Higher ECog-12 was associated with greater decline in global cognitive performance (ECog-12 global: B = -0.17, standard error [SE] = 0.02; ECog-12 executive: B = -0.15, SE = 0.02; ECog-12 memory: B = -0.14, SE = 0.02, p's < 0.001). DISCUSSION: These results support the link between subjective reports of cognitive decline and objectively measured 7-year cognitive decline in community-dwelling, middle-aged, and older Hispanic/Latino adults. HIGHLIGHTS: We found that nearly two-thirds of diverse middle-aged and older Hispanics/Latinos reported cognitive concerns in a large and representative population study. Self-reported subjective experiences of cognitive decline reflect objective cognitive decline in US Hispanics/Latinos. The relationship is stronger among men compared to women. The relationship between subjective and objective changes to memory are stronger in those with cognitive concerns, and remain even in cognitively healthy individuals.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.14232
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
Funders: Office of Dietary Supplements, University of Miami, University of North Carolina, Northwestern University, San Diego State University, Institut National Du Cancer, National Institutes of Health, Albert Einstein College of Medicine, Yeshiva University, Gillings School of Public Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities
Awards: G1004541261, G1042216835, G1064233440, G1081972346, G1155380102, G1301356587, G1312369436, Hispanic Community Health Study, G1455175283, Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), G1587824183, G1666450717, MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of Latinos, G1917633662, G2135211244, G2135293100, G2215135821, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2501967490, G2528054427, G2575730562, G2644289446, G2866617920, G2970637568, G3062787641, G3259176005, Hispanic Community Health Study, G3677686024, G3722034730, G3838006641, G3952816605, G4121762840, G4196558080, Hispanic Community Health Study, G4421869008, G4552920371, San Diego Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Program, G4860668542, G4989378220, SDSU FUERTE: Faculty United towards Excellence in Research and Transformational Engagement, G528357465, G5365244667, G543802643, G555858244, G5739677117, G5878028785, G5906656038, G6075306088, G6156511736, G61781031, G6585687856, G6744188800, G7057037114, G7203655167, G7239480477, G7272721675, G7278742613, G7408420985, G7513901258, G7678550560, Exploring Sleep in Neurocognitive Aging and Alzheimer's Research (eSANAR), G8102260223, G820454163, G8386326007, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8840902395, G8904081916, G8932431361, G9000199330, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30
OpenAlex ID: W4402278425