Work

Primary neurolymphomatosis with MAG antibody: a case report

Year: 2024

Type: article

Abstract: Neurolymphomatosis (NL) is a rare neurologic manifestation of non-Hodgkin lymphoma (NHL) with poor prognosis. Investigations including MRI, PET/CT, nerve biopsy and cerebrospinal fluid (CSF) analysis can aid the diagnosis of NL. In this study, we presented a case of NL with co-existing myelin-associated glycoprotein (MAG) antibody. The patient first presented with symptoms of peripheral neuropathy involving multiple cranial nerves and cauda equina, and later developed obstructive hydrocephalus and deep matter lesions. He also had persistently positive MAG antibody, but did not develop electrophysiologically proven neuropathy and monoclonal immunoglobulin. The final brain biopsy confirmed diffuse large B cell lymphoma.

Source: BMC Neurology

DOI: 10.1186/s12883-024-03798-7

Authors: Honglian Zhang, Si Chen, Jing Li, Huan Yang, Yue-Bei Luo

Institutions: First Affiliated Hospital of Jiangxi Medical College, Jiangxi Provincial People's Hospital, Xiangya Hospital Central South University, Nanchang Medical College, Central South University

Language: English

Topic: CNS Lymphoma Diagnosis and Treatment

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890