Dearomative Addition of Carboranyl Anions to Isoquinolinium Salts and Subsequent Reduction to Access Carborane‐Functionalized 1,2‐Dihydroisoquinolines and 1,2,3,4‐Tetrahydroisoquinolines
Year: 2024
Type: article
Abstract: A dearomative addition of readily available carboranyllithium reagents to isoquinolinium salts gave a series of carborane cage C‐substituted 1,2‐dihydroisoquinolines in 43–85 % yields. Subsequent hydrogenation enabled the facile synthesis of corresponding carboranyl 1,2,3,4‐tetrahydroisoquinolines in 65–95 % yields. The addition‐reduction pathway is applicable to a wide range of substituted isoquinolinium salts and o‐carborane or m‐carborane.
Authors: Yun‐Fan Gao, Chen‐Ming Xu, Ming‐Hui Yu, Yongna Zhang, Xiao‐Jun Wu, You‐Qing Wang
Institution: Henan University
Language: English
Topic: Boron Compounds in Chemistry
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4402286057