Work

Comparative Metabolism of the Humantenirine in Liver Microsomes from Pigs, Goats, and Humans

Year: 2024

Type: article

Abstract: Gelsemium elegans Benth (G. elegans) is a traditional medicinal plant; however, it is highly toxic, and toxicity varies significantly between species. The cause of this difference has not been clarified. Humantenirine is an important toxic alkaloid in G. elegans, and its metabolism has been poorly studied. This study aimed to compare the different metabolites formed by human liver microsomes, pig liver microsomes, and goat liver microsomes.

Source: Future Integrative Medicine

DOI: 10.14218/fim.2024.00029

Authors: Yunfan Wang, Xuejia Qi, Mengting Zuo, Zhaoying Liu

Institution: Hunan Agricultural University

Language: English

Topic: Plant-based Medicinal Research

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Natural Science Foundation of China