Work

Design and Development of Long-Term Therapy for Corneal Repair and Healing – ‘Nanoparticles-in-Dual-Gels’

Year: 2024

Type: article

Abstract: Objective: We aimed to develop a dual-gel cocktail therapy that would fill the treatment gap with safety and patient adherence in lieu of invasive procedures for corneal wound management and self-healing. For this, PLGA-PPS-based nanoparticles (NPs)-loaded with dexamethasone (DEX), and rapamycin (RAPA) are embedded in the stimuli-responsive dual-gels assembly, that consists of thermo-responsive poloxamer (trPol) and photo-responsive gelatin methyl acrylate (prGelMa)- based hydrogels for long-term drug release.

Source: American Journal of Pharmaceutical Education

DOI: 10.1016/j.ajpe.2024.100918

Authors: Kate A. Montreuil, Neeraj Thakur, Brooke T. Robbins, Brototi Chakrabarty, Vibhuti Agrahari

Institution: University of Oklahoma

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400