Life-period associations of body mass index with adult carotid intima-media thickness: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study
Year: 2024
Type: article
Abstract: OBJECTIVE: Child and adult body mass index (BMI) associates with adult carotid artery intima-media thickness (cIMT). However, the relative contribution of BMI at different life-periods on adult cIMT has not been quantified. This study aimed to determine the life-course model that best explains the relative contribution of BMI at different life-periods (childhood, adolescence, and young-adulthood) on cIMT in adulthood. METHODS: BMI was calculated from direct measurements of height and weight at up to seven time-points from childhood to adulthood (1973-2007) among 2485 participants of the Cardiovascular Risk in Young Finns Study (YFS) and 1271 participants in the Bogalusa Heart Study (BHS). BMI measures at three ages representative of childhood (9-years), adolescence (18 years) and young-adulthood (30 years) life-periods were used. B-mode ultrasound was used to measure common cIMT in adulthood (>30 years). Associations were evaluated using the Bayesian relative life-course exposure model. RESULTS: In both cohorts, cumulative exposure to higher levels of BMI across the life-course was associated with greater cIMT. Of the examined life-periods, BMI in young-adulthood provided the greatest relative contribution towards the development of adult cIMT for YFS (49.9 %, 95 % CrI = 34-68 %) and white BHS participants (48.6 %, 95 % CrI = 9-86 %), whereas BMI in childhood had the greatest relative contribution for black BHS participants (54.0 %, 95 % CrI = 8-89 %). CONCLUSION: Although our data suggest sensitive periods in the life-course where prevention and intervention aimed at reducing BMI might provide most benefit in limiting the effects of BMI on cIMT, maintaining lower BMI across the life-course appears to be optimal.
Source: Preventive Medicine
Institutions: University of Tasmania, Menzies Institute for Medical Research, Tasmanian Government, Tasmanian Department of Health, University of South Australia, University of Turku, Turku University Hospital, Tulane University, Tampere University, Tampere University Hospital, University of Tampere, Royal Children's Hospital, The University of Melbourne, Murdoch Children's Research Institute, University of Iowa, Baker Heart and Diabetes Institute
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,500
Funders: American Heart Association, Yrjö Jahnssonin Säätiö, Kela, Academy of Finland, Suomen Kulttuurirahasto, Juho Vainion Säätiö, Signe ja Ane Gyllenbergin Säätiö, Emil Aaltosen Säätiö, Sydäntutkimussäätiö, Sigrid Juséliuksen Säätiö, Tampereen Tuberkuloosisäätiö, Diabetesliitto, Paavo Nurmen Säätiö, Tays, Syöpäsäätiö, Turun Yliopistollinen Keskussairaala, Animal Health Australia, Suomen kliinisen kemian yhdistys, National Institutes of Health, European Research Council, Horizon 2020, National Institute on Aging, National Heart, Lung, and Blood Institute
Awards: G1000894810, G1037428335, G1255523522, Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-up, G1481066947, G1601895641, G1763104746, G1836603902, G1872575776, G1891033315, G198835066, G2026946236, G2106865311, G2124615729, G2230772921, G2324773484, G2330237237, G234837756, G24679314, G247187792, G2513778610, G2641752829, G2714235510, G283320287, G2942749444, Integrated Digital Technology Platform for Optimization of Precision Brain Health, G3111916513, G3213590351, G33539551, G3482151444, G3582688621, G3858258543, G4139205196, G4351223834, G4530067370, G4655867613, G4790202255, Life-long stability, heritability and responsiveness of short non-coding RNA levels in relation to the risk of cardiometabolic diseases, G4965406020, G5090981026, G5208171454, G523551622, G5474452856, G5489727732, G5512925732, G5535806742, G5646563246, Ancestral environmental exposures and offspring health – a multigenerational epidemiologic cohort study across 3 generations, Life-long stability, transgenerational heritability and responsiveness of circulatory and sperm short non-coding RNAs in relation to the risk of cardiometabolic diseases, G5770909501, G6164432047, G6310393984, G6338156093, G692875121, G69797456, Lifelong and transgenerational epigenetic profiles in relation to the development of cardiometabolic diseases, G7169185942, G7292637994, G7540798381, G7793226659, G793006034, G8098387459, G8428091697, G8709794931, G9000074058, G9000167962, G9000169072, G9000193306, G9000221710, G9000229545, G9000275993, I3C DECADE: Developmental Epidemiology of Childhood Cardiovascular Exposures and Alzheimer’s Dementia
OpenAlex ID: W4402298186