Work

The inter-relationship between Helicobacter pylori infection, dementia and mortality in type 2 diabetes: The Fremantle Diabetes Study Phase I

Year: 2024

Type: article

Abstract: Given sparse relevant data, the aim of this study was to determine whether Helicobacter pylori infection, including cytotoxin-associated gene-A (CagA) producing strains, is associated with dementia in type 2 diabetes (T2DM). Longitudinal data from 1115 participants in the community-based Fremantle Diabetes Study Phase I (mean age 64.0 years, 48.0 % males; 38.0 % H. pylori seronegative, 24.3 % H. pylori seropositive/CagA seronegative, and 37.7 % H. pylori /CagA seropositive at baseline) were analyzed. During up to 19 years of follow-up, 50.3 % and 83.5 % of participants without and with incident dementia, respectively, died. In Cox proportional hazards models, H. pylori /CagA seropositivity (hazard ratio (95 % CI) 1.68 (1.15, 2.46), P = 0.008), but not H. pylori seropositivity/CagA seronegativity ( P = 0.541) was an independent predictor of incident dementia, but neither H. pylori seropositivity/CagA seronegativity nor H. pylori /CagA seropositivity were significant predictors in competing risks models ( P ≥ 0.280). Although CagA seropositivity in T2DM may have a contributory etiologic role in the risk of dementia, this may be through its association with reduced cardiovascular/all-cause mortality. • Whether H. pylori infection increases dementia risk in type 2 diabetes is unclear. • Factors influencing dementia incidence were assessed in a community-based cohort. • H. pylori -associated CagA seropositivity independently predicted incident dementia. • This association was no longer seen when adjusting for the competing risk of death. • This finding has implications for other studies assessing dementia risk factors.

Source: Journal of Diabetes and its Complications

DOI: 10.1016/j.jdiacomp.2024.108854

Authors: Timothy M.E. Davis, David G. Bruce, Katrin Schimke, S.A. Paul Chubb, Wendy A. Davis

Institutions: The University of Western Australia, Fremantle Hospital

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,220