Work

MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression

Year: 2024

Type: article

Abstract: . Overall, our study suggests that MTA2 knockdown suppresses osteosarcoma cell metastasis by decreasing uPA expression via ERK signaling. This finding provides new insight into potential treatment strategies against osteosarcoma metastasis by targeting MTA2.

Source: Aging

DOI: 10.18632/aging.206070

Authors: Chun Tseng, Chien-Min Chen, Yi-Hsien Hsieh, Chia-Yu Lin, Jian-Wen Chen, Pang-Hsuan Hsiao, Yi-Chin Fong, Pei-Han Wang, Pei-Ni Chen, Renn-Chia Lin

Institutions: China Medical University, China Medical University Beigang Hospital, China Medical University Hospital, National Chung Cheng University, Changhua Christian Hospital, National Chin-Yi University of Technology, Chung Shan Medical University, Chung Shan Medical University Hospital

Language: English

Topic: Mechanisms of cancer metastasis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Academia Sinica, China Medical University, Chung Shan Medical University, Chung Shan Medical University Hospital

OpenAlex ID: W4402309863

FWCI:

Cites: 38

Cited by:

Related to: 10