Work

Enzymatic synthesis of S -adenosyl- l -homocysteine and its nucleoside analogs from racemic homocysteine thiolactone

Year: 2024

Type: article

Abstract: One-pot enzyme-catalyzed synthesis of S -adenosyl homocysteine and derivatives thereof from racemic homocysteine thiolactone and adenosine or other nucleosides provides simple and scalable access to cofactors for methyltransferase biocatalysis.

Source: Chemical Science

DOI: 10.1039/d4sc03801k

Authors: Xiaojin Wen, Viviane Leopold, Florian P. Seebeck

Institution: University of Basel

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: National Science Foundation, Camille and Henry Dreyfus Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Awards: Diversity-oriented biocatalytic production of complex polyamines, G3188738659, NCCR MSE: Molecular Systems Engineering (phase III)