Frequency of Myocardial Infarction and Comparison of Streptokinase Therapy Success Rate Based on Gender and Diabetes Status
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Acute ST-elevation myocardial infarction (STEMI) is a major cause of morbidity and mortality. Streptokinase is a widely used thrombolytic agent, but its efficacy may vary based on diabetic status and gender.Objective: To compare the success rate of streptokinase therapy in STEMI patients based on diabetic status and gender.Methods: A prospective cohort study was conducted in the Emergency Department of MTI Lady Reading Hospital, Peshawar, involving 310 STEMI patients treated with streptokinase. Patients were grouped by diabetic status (diabetic: 208; non-diabetic: 102) and gender (male: 183; female: 127). The success of therapy was defined as ≥70% ST-segment resolution on an ECG taken 90 minutes post-therapy. Data were analyzed using SPSS version 25 with Chi-square tests for categorical variables.Results: Streptokinase success rates were higher in non-diabetic patients (76.5%) compared to diabetic patients (49.5%). Male patients showed a higher success rate (74.9%) than females (66.1%). Among non-diabetics, males had the highest success rate (92.9%), while diabetic females had the lowest (40.4%).Conclusion: Streptokinase is more effective in non-diabetic and male STEMI patients. Gender and diabetic status should guide therapy decisions.
Authors: Muhammad Irfan, Atta ul Wadood, Sajjad Ur Rahman, Ejaz Ali Khan, Shahab Afridi
Institutions: Peshawar Institute of Cardiology - MTI, Ayub Medical College
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4402320635