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One‐Pot Synthesis of 2,4,6‐Trialkoxy‐ and Triaryloxybenzoates by Cs2CO3‐Mediated Tandem Dimerization/(3+3) Cyclocondensation of 1,3‐Acetonedicarboxylates

Year: 2024

Type: article

Abstract: In this study, Cs2CO3‐mediated one‐pot tandem dimerization/(3+3) cyclocondensation of 1,3‐acetonedicarboxylates followed by substitution of alkyl or aryl halides was developed to construct functionalized 2,4,6‐trialkoxy‐ and triaryloxybenzoates. In the effective reaction, the core benzene system was formed in a single‐step process under open‐vessel conditions. A plausible mechanism for this reaction is proposed and discussed herein.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202400942

Authors: Meng‐Yang Chang, Chin‐Huey Ho

Institutions: Kaohsiung Medical University, National Pingtung University of Science and Technology, Kaohsiung Medical University Chung-Ho Memorial Hospital

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Science and Technology Council

OpenAlex ID: W4402324652

FWCI:

Cites: 34

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Related to: 10