Work

Rodent Models of Streptozotocin-Induced Diabetes as Suitable Paradigms for Studying Diabetic Kidney Disease

Year: 2024

Type: article

Abstract: The purpose of this correspondence is to highlight the usefulness of Streptozotocin (STZ)-induced type 1 diabetes for studying Diabetic Kidney Disease (DKD) which is also known as diabetic nephropathy.1 DKD is a major microvascular complication of diabetes regardless of type 1 or type 2 diabetes. DKD is also a leading cause for the development of end stage renal failure.1 The main features of DKD is thickening of the glomerular basement membrane caused by accumulation of matric glycoproteins and collagens, resulting in increased albumin secretion and a decreased glomerular filtration rate. Read more. . .

Source: Free Radicals and Antioxidants

DOI: 10.5530/fra.2024.1.5

Authors: Haoxin Liu, Yucheng Wang, Ying Wang, Liang-Jun Yan

Institutions: University of North Texas Health Science Center, University of North Texas System, Chinese Academy of Medical Sciences & Peking Union Medical College

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Diabetes Action Research and Education Foundation, University of North Texas