Mitragynine and morphine produce dose-dependent bimodal action on food but not water intake in rats
Year: 2024
Type: article
Abstract: This study reveals that morphine and the kratom alkaloid mitragynine produce dose-dependent effects on feeding in rats. Low doses stimulate food intake via opioid pathways, while high doses decrease consumption through nonopioid mechanisms. Morphine potently suppresses water intake at all doses, whereas only high doses of mitragynine reduce drinking. These findings provide novel insights into the complex opioid and nonopioid mechanisms underlying the effects of mitragynine on ingestive behaviors.
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
Funder: National Institute on Drug Abuse
OpenAlex ID: W4402350764