EP17.23: The connection between first trimester biochemical screening results and the risk of neonatal complications post‐delivery
Year: 2024
Type: conference-abstract
Abstract: The study aimed to correlate the outcomes of biochemical tests initially used for assessing the risk of fetal chromosomal aberrations (Pregnancy-Associated Plasma Protein-A [PAPP-A] and free beta-human Chorionic Gonadotropin [fβ-hCG]) collected between the 11th and 13+6 weeks of gestation with the risk of neonatal complications in newborns. We included patients who underwent prenatal screening in the first trimester of pregnancy between the 11th and 13+6 weeks of gestation, followed by a follow-up until delivery. We recorded the incidence of neonatal complications such as severe and moderate newborn condition at 1 minute postbirth (Apgar score < 8), and admission to the Neonatal Intensive Care Unit (NICU). The study encompassed 742 patients, and the results are presented in table 1. Mothers of newborns with a poorer clinical condition at birth had a statistically lower median concentration of PAPP-A and PAPP-A MoM in the first trimester of pregnancy. We observed that newborns with lower concentrations of free β-hCG and β-hCG MoM in the first trimester had an increased risk of hospitalization in the NICU. Low concentrations of free β-hCG in the first trimester of pregnancy may be associated with neonatal hospitalization in the NICU. Lower PAPP-A concentrations might be linked with poorer neonatal outcomes, as assessed by the Apgar score.
DOI: 10.1002/uog.28680
Authors: S. Grzegorz, A. Zmelonek‐Znamirowska, K. Szwabowicz, J. Armanska, M. Mlodawska, J. Mlodawski
Institutions: Jan Kochanowski University, Wojewódzki Szpital Zespolony
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4402358022