Work

OC20.04: Perinatal outcomes of early Twin–twin transfusion syndrome: an international multicentre study

Year: 2024

Type: conference-abstract

Abstract: to report on perinatal survival of MCDA twin pregnancies complicated by early Twin–twin transfusion syndrome (TTTS) according to their management. This was an international multicentre cohort study. Monoamniotic twins, triplets or higher order multiples and fetuses with chromosomal/structural anomalies were excluded. Demographic data, gestational age (GA) and Quintero stage at diagnosis, type of management (laser, expectant, selective termination(sTOP), termination of the whole pregnancy (TOP) and others) were ascertained from the patient records. The main outcome was survival up to 28 days. Six-hundred seventy-eight women were diagnosed with early TTTS at median 17 (IQR 16.4-17.6) weeks. Stage III was the most common (44%) at presentation. Laser surgery was the commonest management (79.9%) followed by expectant (9.9%). Table 1 reports on survival according to Quintero Stage at diagnosis and according to management (laser vs. expectant vs. sTOP). In the laser group, 43.6%, 23.8% and 20.8% pregnancies had two, one and no surviving fetuses, respectively. In the expectant management group, 41.8%, 10.4% and 41.8% had two, one and no surviving fetuses, respectively. Laser was associated with higher survival rates compared to expectant management (at least one survivor in 67.4% vs. 52.2%, p = 0.03). Laser treatment was offered in the majority of early TTTS which mainly presented at II or higher Quintero stage. In early TTTS Laser treatment was associated with higher survival rates compared to expectant management. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Source: Ultrasound in Obstetrics and Gynecology

DOI: 10.1002/uog.27863

Authors: A. Khalil, F.G. Sileo, S. Prasad, K. Hecher

Institutions: University of London, St George's, University of London, University of Modena and Reggio Emilia, St George’s University Hospitals NHS Foundation Trust, University Medical Center Hamburg-Eppendorf

Language: English

Topic: Assisted Reproductive Technology and Twin Pregnancy

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4402358173

Cites:

Cited by:

Related to: 10