Year: 2024
Type: conference-abstract
Abstract: Objectives: To assess the association of low fetal fraction (FF) of cfDNA and obstetric complications.Methods: cfDNA screening for chromosomal defects was performed in 3048 pregnant women at the GENNET screening centre in the period 2019 -2022.Tests were collected between 10 and 20 weeks of gestation.Pregnancy complications such as pregnancy-induced hypertension(PIH), pre-eclampsia (PE), small gestation age (SGA), preterm delivery and gestational diabetes mellitus (GDM) were retrospectively evaluated in a group of pregnant women with low FF cfDNA ≤4% and a control group with FF cfDNA >4%.Results: In 47 pregnant women (1.5% of tests), FF ≤4%.Outcome was obtained from 21 pregnant women.The prevalence of PIH, PE, SGA, preterm delivery < 37 weeks and GDM were 25%, 12.5%, 0% and 25%, respectively.The incidence of PIH and GDM was higher in women with low FF compared to the reference group.Conclusions: In our study, we were able to demonstrate the association of low FF with pregnancy complications -PIH and GDM.Due to the small number of cfDNA tests evaluated, further study with larger sample size is needed to test the hypothesis.EP17.38
DOI: 10.1002/uog.28698
Institutions: Hôpital Farhat Hached, University of Sousse
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4402358683