EP12.03: Circulating angiogenic factors levels in women with hypertensive disorders of pregnancy according to the baseline hemodynamic findings
Year: 2024
Type: conference-abstract
Abstract: To assess in women with hypertensive disorders of pregnancy (HDP) if the predictive value of sFLT-1/PlGF ratio for adverse outcomes is influenced by the hemodynamic phenotype. Retrospective study including a cohort of women with new-onset HDP carrying a singleton viable pregnancy from 22 to 36 gestational weeks. A non-invasive assessment of the main maternal hemodynamic parameters [Cardiac Output (CO), Systemic Vascular Resistance (SVR)] was done upon hospital admission using USCOM-1A. The hemodynamic phenotype was classified as “hypodynamic” in case of low CO[<5L/min] and/or high SVR [>1400 dynes*s*cm-5] or as “non-hypodynamic” in case of normal or high CO [>5 L/min] and/or low SVR [<1400 dynes*s*cm-5]. The values of sFLT-1 and PlGF were assessed on maternal serum upon hospital admission and their ratio was calculated. An adverse composite maternal outcome (ACMO) was defined in presence of at least one among: severe hypertension or placental abruption or occurrence of end-organ dysfunction as defined by ISSHP guidelines 2021. A composite of adverse neonatal outcome (ACNO) included birthweight below the 10th percentile (small for gestational age), or fetal/neonatal death. Among the 93 women included, 57 (61.2%) were categorised as hypodynamic and 36 (38.8%) as non-hypodynamic. sFLT-1/PLFG ratio at admission was significantly higher in the former group compare with the latter (301[93.1-787] vs. 52.5 [10.0-257.0]). A significant association between SFLT-1/PLGF ratio and an ACMO (p = 0.02) and an ACNO (p = 0.007) was reported only in the group of women defined with a “hypodynamic” profile. sFLT1/PlGF ratio is associated with the occurrence of an adverse maternal and neonatal outcome only in women with a hypodynamic profile.
DOI: 10.1002/uog.28555
Authors: M. Taverna, B. Valentini, E. di Pasquo, A. Dall'Asta, M. Capurso, P. D'Amario, V.A. Degennaro, A. Casciaro, T. Ghi
Institution: University of Parma
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4402360923