Work

Efficient Solution-Phase Dipeptide Synthesis Using Titanium Tetrachloride and Microwave Heating

Year: 2024

Type: article

Abstract: Microwaves have been successfully employed in the Lewis acid titanium tetrachloride-assisted synthesis of peptide systems. Dipeptide systems with their amino function differently protected with urethane protecting groups have been synthesized in short periods of time and with high yields. The formation of the peptide bond between the two reacting amino acids was achieved in pyridine by using titanium tetrachloride as a condensing agent and heating the reaction mixture with a microwave reactor. The reaction conditions are compatible with amino acids featuring various side chains and different protecting groups on both the amino function and side chains. Additionally, the substrates retain their chiral integrity after reaction.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms25179729

Authors: Palmira Alessia Cavallaro, Marzia De Santo, Rocco Marinaro, Emilia Lucia Belsito, Angelo Liguori, Antonella Leggio

Institution: University of Calabria

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,296

Funders: European Commission, Ministero dell’Istruzione, dell’Università e della Ricerca