Near-infrared irradiation study of honey-mediated Au nanoparticles for photothermal therapy
Year: 2024
Type: article
Abstract: Gold nanoparticles synthesized via honey-mediated chemical reduction have desirable features that make them ideal candidates for nanoparticle-assisted photothermal therapy (N-PTT). However, their photothermal properties have not been previously explored. In this study, after synthesis and characterization (structural and optical) of the HM-AuNPs, we investigated their photothermal conversion efficiency (η) and absorption cross section (σabs) in aqueous solution, cytotoxic effects in in vitro MDA-MB-468 breast cancer cell culture, and temperature profiles in agarose gel under 810 nm NIR irradiation. The results showed that ≈15 nm and primarily spherical HM-AuNPs had η values of up to 40% and an average σabs of 2.15±0.08×10−18 m2. Furthermore, cell viability was reduced to about 52% and the temperature profile in agarose gel had the typical radially increasing topology. Collectively, the findings show that HM-AuNPs can be used in N-PTT.
Source: Journal of Applied Physics
DOI: 10.1063/5.0219146
Institutions: University of Ghana, 37 Military Hospital, Augusta University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,500
Funder: Carnegie Corporation of New York
OpenAlex ID: W4402372558