E015 Neural correlates of cardiorespiratory activities in presymptomatic Huntington’s disease
Year: 2024
Type: conference-abstract
Abstract: Background Autonomic dysfunction has been described in Huntington’s disease (HD);1–6 however, little is known about its neural underpinnings. Aims We evaluated the integrity of the neural circuitry involving cardiac and respiratory functions in gene-positive pre-symptomatic individuals (PHD), by determining the correlations of spontaneous cerebral hemodynamic fluctuations with variations in heart rate (HR) and breath-by-breath oxygen-carbon dioxide exchange ratio (bER). Methods Eighteen PHD and 22 healthy participants (HC) were included. Procedures were approved by the Institutional Review Board at Massachusetts General Hospital and signed informed consent was obtained from participants. MRI brain scanning was performed on a 3-Tesla scanner. Blood oxygen-level dependent (BOLD) images were acquired at rest (TR=1250ms,TE=30ms,voxel size=2.3×2.3×2.4 mm,duration=10 minutes), with simultaneous measurements of partial pressures of carbon dioxide and oxygen, and heart rate (HR). The time series of HR and bER were correlated with BOLD signal changes (ΔBOLD) using a Hilbert transform analysis, as described previously.7 Voxel-level multivariate regression models were constructed to compare the brain maps of HR-ΔBOLD and bER-ΔBOLD correlations by group (PHD vs HC) with age as a covariate. Results Both HR-ΔBOLD and bER-ΔBOLD correlations were smaller in several brain/brainstem regions in PHD than HC (figure 1). Conclusion Our results suggest that dysfunction of the neural circuitry responsible for cardiac and respiratory functions, may underlie early autonomic dysfunction in HD. References Schultz JL, Harshman LA, Kamholz JA, Nopoulos PC. Auton Neurosci 2021;231:102775. Kobal J, Melik Z, Cankar K, Strucl M. J Neurol 2014;261:1119–1125. Assante R, Salvatore E, Nappi C, et al. J Nucl Cardiol 2022;29:642–648. Fischer J, Oepen G, Matthys H. Biological Psychology 1983;16:286. Leopold NA, Kagel MC, Berkowitz L, Stafford S. J Neurol 1985;232:87. Morton AJ. Exp Neurol 2013;243:34–44. Chan ST, Evans KC, Song TY, et al. PLoS One 2020;15:e0238946.
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4402374659