Year: 2024
Type: conference-abstract
Abstract: Background Autonomic dysfunction has been described Huntington’s disease (HD), but the involvement of the Autonomic Nervous System has not been clarified yet. Aims To describe any changes of cardiovascular autonomic function. Methods It is a cross-sectional study, including 16 manifest subjects, compared with 16 age- and sex-matched healthy controls. All subjects underwent to clinical assessment and a complete cardiovascular reflex tests session (CRTs). Results During the Tilt Table Test, patients with HD showed a lesser increase in blood pressure values at the 3rd and 10th minute after standing, statistically significant for both systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the 3rd minute and for SBP at the 10th minute. During the Valsalva maneuver, patients showed a statistically significant lower overshoot (mean value, range; 28, 20.8-34)] compared to controls (43.5, 35-55.3). During the Handgrip maneuver, the increase in SBP values was lower (21.5, 15.5-32.8) compared to controls (35.5, 29.3-41.8), with a trend towards significance (p-value = 0.053). Conclusions HD subjects showed a very mild dysfunction of sympathetic vasoconstrictor efferences with an intact cardiovagal control of heart rate.
Authors: Giannicola Carrozzo, Pietro Guaraldi, Pietro Cortelli, Giorgio Barletta, Cesa Lorella Maria Scaglione
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4402374676