Year: 2024
Type: article
Abstract: The synthesis of one achiral and two chiral propylene‐bridged dititanocenes and their evaluation as catalysts in titanium(III) catalyzed ketone‐nitrile coupling reactions are reported. A reaction progress kinetics analysis of the cross‐coupling between acetophenone and benzyl cyanide reveals that, using a dinuclear titanocene catalyst, the order in catalyst is reduced from two to one in comparison to a mononuclear catalyst. Although the obtained coupling yields and enantioselectivities did not reach the results obtained with the latter, these examples constitute a proof of concept for the templated C─C coupling through coordination of ketone and nitrile to the two tethered titanium centers of a dinuclear catalyst.
Source: ChemCatChem
Institutions: University of Freiburg, Uppsala University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,330
Funder: Deutsche Forschungsgemeinschaft
OpenAlex ID: W4402377503