Work

Bacterial lipopolysaccharide inhibits free thiamin uptake along the intestinal tract via interference with membrane expression of thiamin transporters 1 and 2

Year: 2024

Type: article

Abstract: This study shows that the exposure of gut epithelial cells to bacterial LPS negatively impact the uptake process of the free form of vitamin B1 (i.e., thiamin). This appears to be mediated via suppression in the level of thiamin transporters 1 and 2 (THTR-1 and -2) expression at the cell membrane and involves a protein kinase A (PKA) signaling pathway.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00570.2024

Authors: Selvaraj Anthonymuthu, Subrata Sabui, Kameron Isaiah Manzon, Alaullah Sheikh, James M. Fleckenstein, Hamid M. Said

Institutions: University of California, Irvine, Tibor Rubin VA Medical Center, Washington University in St. Louis, St. Louis VA Medical Center, John Cochran VA Medical Center, VA St. Louis Health Care System

Language: English

Topic: Alcoholism and Thiamine Deficiency

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Common Fund

Awards: Physiology/Pathophysiology of Vitamin B1 Transport in Pancreatic Acinar Cells, G1165852820, G1258650856, G1297504306, G1334362104, G3382911935, G444632500, G7056102258, G7480867188, G7554326720, G805577297, G8152750745, G8339405863, G866708820, Molecular Pathogenesis of enterotoxigenic E. coli associated enteropathy, Novel Antigen Identification for an enterotoxigenic E coli vaccine, Host-environment interactions in the pathophysiology of digestive disease

OpenAlex ID: W4402377885

FWCI: 1.143

Cites: 67

Cited by: 5

Related to: 10