Work

All Optic-Fiber Waveguide-Coupled SPR Sensor for CRP Sensing Based on Dielectric Layer and Poly-Dopamine

Year: 2024

Type: article

Abstract: We developed an all optic-fiber waveguide-coupled surface plasmon resonance (SPR) sensor using zirconium disulfide (ZrS 2 ) and poly-dopamine (PDA) as the dielectric layer and biological cross-linker, respectively. This sensor can be employed to monitor the entire process of the C-reactive protein (CRP) sensing, including antibody modification and antigen detection. The design and the optimization of the optical fiber waveguide-coupled SPR sensor were realized, based on the transfer matrix method and first-principles calculations. The sensor was fabricated and characterized according to the optimized parameters. The experimental setup was implemented to measure the entire process of antibody modification and antigen detection for CRP with the detection limit of 3.21 pmol·mL −1 , and the specificity tests were also carried out.

Source: Photonic Sensors

DOI: 10.1007/s13320-024-0734-0

Authors: Jinying Ma, Shixin Li, Xiangdong Huang, Junfeng Jiang, Tianhua Xu, Tiegen Liu

Institutions: Tianjin University of Technology and Education, Tianjin University, University of Warwick

Language: English

Topic: Advanced Fiber Optic Sensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China

Awards: G1467341580, G4193086420