Work

In silico structural studies on the vesicular neutral amino acid transporter NTT4 (SLC6A17)

Year: 2024

Type: article

Abstract: NTT4 is one of the neutral amino acid transporters that regulate neural concentration of precursors for glutamate biosynthesis. Here, we provide insight into the structure of NTT4 and rationalize substrate selectivity. Furthermore, we demonstrate how the mutations associated with mental disabilities imply malfunction of the transporter at the molecular level. We also compared the structures of NTT4 and B 0 AT2 (SLC6A15), which is a close homolog, sharing 66 % of the common amino acids. Our analyses may be useful in the search for compounds that inhibit substrate transport. Moreover, they allow a better understanding of the function of these transporters.

Source: Computational and Structural Biotechnology Journal

DOI: 10.1016/j.csbj.2024.09.004

Authors: Jędrzej Kukułowicz, Marek Bajda

Institution: Jagiellonian University

Language: English

Topic: Amino Acid Enzymes and Metabolism

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,230

Funders: Uniwersytet Jagielloński Collegium Medicum, Uniwersytet Jagielloński w Krakowie