Work

Scission-Enhanced Molecular Imaging (SEMI)

Year: 2024

Type: article

Abstract: Positron emission tomography (PET) imaging methods have advanced our understanding of human biology, while targeted radiotherapeutic drug treatments are now routinely used clinically. The field is expected to grow considerably based on an expanding repertoire of available affinity ligands, radionuclides, conjugation chemistries, and their FDA approvals. With this increasing use, strategies for dose reduction have become of high interest to protect patients from unnecessary and off-target toxicity. Here, we describe a simple and powerful method, scission-enhanced molecular imaging (SEMI). The technique allows for rapid corporeal elimination of radionuclides once imaging or theranostic treatment is completed and relies on "click-to-release" bioorthogonal linkers.

Source: Bioconjugate Chemistry

DOI: 10.1021/acs.bioconjchem.4c00337

Authors: Jeremy M. Quintana, Jonathan C. T. Carlson, Ella Scott, Thomas S. C. Ng, Miles A. Miller, Ralph Weissleder

Institutions: Massachusetts General Hospital, Center for Systems Biology, Harvard University

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500