Work

EBV‐Positive Classic Hodgkin Lymphoma and Primary Nodal T‐Cell/NK‐Cell Lymphoma Arising in the Background of Follicular Lymphoma

Year: 2024

Type: article

Abstract: EBV-positive primary nodal T-cell/NK cell lymphoma (TNKL) is a rare diagnosis with a poor prognosis. No relationship with follicular lymphoma (FL), classic Hodgkin lymphoma (cHL), or other non-Hodgkin lymphomas is established. We describe a case of Epstein-Barr virus (EBV)-positive cHL and EBV-positive primary nodal TNKL in the background of an antecedent FL, with all 3 subtypes identified in a single lymph node biopsy from an immunocompetent patient. Intensive frontline therapy achieved only a temporary response, with subsequent rapid progression associated with hemophagocytic lymphohistiocytosis (HLH). We discuss the relationship of the three lymphoma subtypes and the potential roles of EBV and immune dysregulation as contributing factors to this previously undescribed composite lymphoma.

Source: Case Reports in Hematology

DOI: 10.1155/2024/8810646

Authors: Suravi Raychaudhuri, Zhao Ming Dong, Scott Knowles, Solomon Graf

Institutions: University of Washington, Fred Hutch Cancer Center, VA Puget Sound Health Care System

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $750