Work

Heteroplasmy in action: tracking mtDNA segregation dynamics

Year: 2024

Type: article

Abstract: Difficulties in tracking the dynamics of heteroplasmy, a state when a single cell contains distinct mtDNA genotypes, have left our understanding of factors influencing it incomplete. New work now provides a powerful approach for monitoring heteroplasmic yeast populations in real-time, and reveals insights into the forces underlying mtDNA variant segregation. A powerful new approach for monitoring heteroplasmic yeast populations in real-time has revealed insights into the forces underlying mtDNA variant segregation.

Source: The EMBO Journal

DOI: 10.1038/s44318-024-00226-x

Authors: Nitish Dua, Anjana Badrinarayanan

Institutions: Scripps Research Institute, National Centre for Biological Sciences

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $6,890

Funder: Human Frontier Science Program