Work

Distribution of mechanical properties of native human ligamentum flavum depending on histopathological changes

Year: 2024

Type: article

Abstract: This study aimed to characterize the mechanical properties of native human ligamentum flavum (LF) and correlate them with histopathological changes. Mechanical property gradients across the cranial, medial, and caudal regions of LF were mapped and compared with histological sections. We also compared lumbar spinal stenosis (LSS) samples with disc herniation (DH) samples as reference material to identify differences in mechanical properties and histopathological features. Our results revealed significant heterogeneity in LF mechanical properties, with local variations correlating with specific histopathological changes such as chondroid metaplasia and loss of elastic fibers. These findings underscore the importance of considering LF heterogeneity in mechanical characterization and provide insights into its behavior under pathological conditions.

Source: Biomedical Physics & Engineering Express

DOI: 10.1088/2057-1976/ad78e2

Authors: Filip Samal, Vojtech Cerny, Petr Kujal, Jakub Jezek, Jiri Skala-Rosenbaum, Josef Sepitka

Institutions: Charles University, University Hospital Kralovske Vinohrady, Czech Technical University in Prague

Language: English

Topic: Spine and Intervertebral Disc Pathology

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,285