Validation of a global method for the simultaneous analysis of polar and non-polar pesticides by online extraction and LC-MS/MS
Year: 2024
Type: article
Abstract: BACKGROUND: Multi-residue methods for pesticide analysis in food are available for many compounds, but polar pesticides are not generally included due to their specific properties, which include high polarity and low molecular weight. Single residue methods are therefore needed for sample preparation, while chromatographic separation often requires derivatization, ion paring, or dedicated methods suitable for polar compounds, mostly ion chromatography and hydrophilic interaction liquid chromatography (HILIC). These challenges affect the important pesticide glyphosate and the related compounds aminomethylphosphonic acid (AMPA) and glufosinate. There are only a few methods including these compounds in large-scale analysis, mostly complex methods based on multidimensional chromatography. RESULTS: , respectively. The result was competitive with previous methods on polar pesticide analysis in beer. SIGNIFICANCE: range from -4.4 to 4.5, using a methodology with single and fast chromatographic separation under conditions compatible with multi-residue analysis by RP-LC-MS/MS. In the case of beer, for which the method was validated, the sample preparation was also performed online, after simple degassing, and sample dilution.
Source: Analytica Chimica Acta
Institution: Sapienza University of Rome
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,070
OpenAlex ID: W4402405647